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Figure 3 | Molecular Cancer

Figure 3

From: SPOCK1 as a potential cancer prognostic marker promotes the proliferation and metastasis of gallbladder cancer cells by activating the PI3K/AKT pathway

Figure 3

Effect of SPOCK1 overexpression and silencing on the growth of GBC cells in vitro . (A) The cells growth rates were determined by CCK-8 proliferation assays at various time points (*P < 0.05, **P < 0.01, and ***P < 0.001). (B) Representative images of colony formation induced by Lv-shNC, Lv-shSPOCK1, MOCK-SGC-996, and SPOCK1-SGC-996 cells. The numbers of colonies were calculated and are depicted in the bar chart (*P < 0.05, **P < 0.01, and ***P < 0.001). (C) Knockdown of SPOCK1 expression inhibited DNA replication in GBC-SD and NOZ cells compared to control as determined by the EdU incorporation assay. Elevated expression of SPOCK1 increased DNA replication in SGC-996 cells.

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Molecular Cancer

ISSN: 1476-4598