Fig. 5

In vivo experiments elucidated the effect of the inhibition of LINRIS in CRC. a Image of orthotopic tumors with or without LINRIS knockdown resected from nude mice. b The tumor weights of the orthotopic tumors with or without LINRIS knockdown. Error bars, SD of five independent experiments. *P < 0.05 or **P < 0.01 versus the control. c and d The volume growth curves of tumors (c) and the tumor weights (d) of two PDX models are shown. Error bars, SD of four independent experiments. *P < 0.05 or **P < 0.01 versus the control. e Representative images of H&E staining and IHC staining of Ki-67, IGF2BP2 and MYC from the tumor sections. Scale bar, 50 μm. f Quantification of the proliferation index (Ki-67 proportion), IGF2BP2 and MYC levels in the tumor sections. *P < 0.05, **P < 0.01