Fig. 6

Correlation among TROJAN, CDK2 and MKI67 in clinical samples. a Correlation between TROJAN and CDK2/MKI67 expression, as detected by qRT-PCR in the FUSCC cohort. The correlations were determined by Pearson correlation analysis. b Correlation between TROJAN (ENST00000624228.1 as a substitute transcript) and CDK2/MKI67 expression in the TCGA cohort. The correlations were determined by Pearson correlation analysis. c Immunohistochemical detection of CDK2 in the FUSCC cohort. The correlations were determined by Pearson correlation analysis. Scale bar: 100 μm. d Schematic diagram of TROJAN regulation of the resistance of ER+ breast cancer to a CDK4/6 inhibitor via NKRF