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Fig. 3 | Molecular Cancer

Fig. 3

From: The circROBO1/KLF5/FUS feedback loop regulates the liver metastasis of breast cancer by inhibiting the selective autophagy of afadin

Fig. 3

circROBO1 promotes carcinogenesis and liver metastasis of BC cells. a Subcutaneous injection model to verify the carcinogenetic potential of circROBO1 overexpression group and control group by IVIS. b The images of xenograft tumor in circROBO1 overexpression group and control group were displayed (n=5). c The volumes of tumor were measured once a week and the growth curves of each group were drawn. d The weight of tumors were measured and analyzed. e and f In vivo inferior hemispleen implantation models to analyze the liver metastasis potential of circROBO1 by IVIS. g and h The metastatic sites vividly increased in circROBO1 overexpression group. Metastatic nodules of livers were labeled by arrows and H&E staining of the livers and tumors were showed. The data are showed as the mean ± SD, *P < 0.05 **P < 0.01, ***P < 0.001

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Molecular Cancer

ISSN: 1476-4598