Fig. 4

The cellular uptake in different conditions. A The cellular uptake of different formulations containing 150Â nM miR-126-3p. B The lysosome escape of Cy5-miR-126-3p. C Scheme illustration of lysosome escape. NCI-H1299 cells were incubated with REMAIN for 1 and 9Â h, respectively. Excitation/Emission: FITC-Phalloidin (488Â nm/525Â nm); Cy5 (633Â nm/670Â nm); DAPI (358Â nm/461Â nm)