Fig. 1

Signatures of Wnt signaling expressing status and their clinical relevance. A The SOX family and Snail, which are critical effectors of the Wnt signaling pathway with transcriptional and pluripotency promotion ability, exhibit significantly abnormal expression patterns. B RNA array and chip sequencing techniques were employed to analyze the expression patterns of the SOX family. C Survival analysis of Wnt signaling family factors demonstrates their negative roles in predicting overall survival and progression-free survival. D KEGG pathway evaluation and ROC-Plotter associated Dep-map calculation were performed to assess the effects of Osimertinib treatment. E The most differentially expressed functional factors and ligands were presented. F By clustering Wnt signaling genes, it was observed that abnormal activation of the Wnt pathway correlates significantly with diverse treatment responses and long-term therapeutic outcomes