Fig. 5

Effects of lower vs. higher anti-CSF1R doses on immune cell infiltrates and circulating cytokines and chemokines in the YUMMER1.7 model. A. YUMMER1.7 endpoint tumor tissue positivity of CD3, CD8, CD68 and CD163 from mice that received a lower anti-CSF1R dose + anti-CD40 and anti-PD-1 and higher anti-CSF1R dose together with anti-CD40 and anti-PD-1 displayed as ratio to control (untreated) tumors. B. Cytokine/ chemokine profiling in YUMMER1.7 mice 24 h after one treatment with PBS (untreated), lower anti-CSF1R dose + anti-CD40 and anti-PD-1 and higher anti-CSF1R dose + anti-CD40 and anti-PD-1. C. Cytokine/chemokine levels in plasma of mice treated with lower anti-CSF1R dose + anti-CD40 and anti-PD-1 and higher anti-CSF1R dose + anti-CD40 and anti-PD-1 collected 24 h post one treatment. ^*p < 0.05