Skip to main content
Fig. 6 | Molecular Cancer

Fig. 6

From: A bedside to bench study of anti-PD-1, anti-CD40, and anti-CSF1R indicates that more is not necessarily better

Fig. 6

Single cell RNA sequencing analysis of YUMMER1.7 shows higher proportion of TAM-II associated with higher anti-CSF1R dose. A. UMAP visualization of cell populations based on gene expression in YUMMER1.7 24 h after no treatment, B. one treatment with lower anti-CSF1R dose + anti-CD40 and anti-PD-1, C. or higher anti-CSF1R dose together with anti-CD40 and anti-PD-1. D. Gene expression of Lgals, Spp1, Arg1, Cd36 and Ctsk in TAM-II of mice treated as indicated. TAM-I = TAM expressing genes involved in both proinflammatory and suppressive functions. TAM-II = TAM expressing genes involved in predominantly suppressive functions

Back to article page

Molecular Cancer

ISSN: 1476-4598