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Fig. 4 | Molecular Cancer

Fig. 4

From: R-loop and diseases: the cell cycle matters

Fig. 4

Cell-cycle-dependent R-loop resolution factor. For the cell-cycle-dependent R-loop factor, the THO complex plays a role in both the G1 phase and the S phase. In addition, Sen1 and Primpol can also resolve it in the S phase. In the G2/M phase, RNase H2 is the principal factor that resolves the RNA portion of the RNA: DNA hybrid strand.

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Molecular Cancer

ISSN: 1476-4598