Fig. 1

Histone demethylation mechanism of KDM5. KDM5 proteins recognize and bind histone tails H3K4me2/3 in chromosomes and then catalyze hydroxylation of methyl groups in the JmjC domain with the assistance of cofactors Fe(II) and 2-OG, followed by hydroxymethyl cleavage to form formaldehyde and produce lysine with one fewer methyl group