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Fig. 5 | Molecular Cancer

Fig. 5

From: KDM5 family as therapeutic targets in breast cancer: Pathogenesis and therapeutic opportunities and challenges

Fig. 5

KDM5 structure. (A) KDM5 family members are 1560–1690 amino acid residues in length and contain six conserved structural domains including JmjN, ARID, PHD1, JmjC, ZnF, and PHD2. In addition, KDM5A and KDM5B have one more PHD3 structural domain than KDM5C and KDM5D. (B) The KDM5 family members are relatively similar in three-dimensional structure. The catalytic core structural domain JmjC is surrounded by ARID, JmjN, ZnF, and PHD1, which co-facilitate the demethylation reaction by binding to specific DNA sequences and target proteins

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Molecular Cancer

ISSN: 1476-4598