Fig. 3
From: Effects of super-enhancers in cancer metastasis: mechanisms and therapeutic targets
Gain or loss of SEs enhances malignant tumor metastasis through either upregulating oncogene expression or downregulating tumor suppressor gene expression. SEs can foster metastasis-related cellular characteristics by modulating key molecular factors associated with proliferation, migration, invasion, cancer stem cells (CSCs) formation, epithelial-mesenchymal transition (EMT), and the tumor microenvironment (TME)