Fig. 2

Roles of circRNAs in tumor immunity. A CircRNAs regulate cancer stemness and affect the antitumor immune response. B CircRNAs regulate immune checkpoints. C CircRNAs influence immune cells infiltration and recruitment by cytokines and chemokines to shape the TIME. D Exo-circRNAs induce NK cells/T cells exhaustion. circRNAs: Circular RNAs; CSCs: Cancer stem cells; TME: tumor microenvironment