The role of microRNAs in the gastric cancer tumor microenvironment

Yu, Xianzhe; Zhang, Yin; Luo, Fengming; Zhou, Qinghua; Zhu, Lingling

doi:10.1186/s12943-024-02084-x

Molecular Cancer

Table 3 miRNAs that play roles in GC chemoresistance

From: The role of microRNAs in the gastric cancer tumor microenvironment

Symbol	Status	Signaling Pathway/ Targets	Function	Effects on chemosensitivity	Resistance	Reference
miR-1	Downregulated	Sorcin	Promote the accumulation of intracellular drugs and enhance apoptosis	Increasing	Adriamycin, Vincristine	[210]
miR-7	Downregulated	LDH-A	Increase apoptosis and caspase-3 activation	Increasing	Cisplatin	[211]
miR-16–1	Downregulated	FUBP1	Inhibit GC proliferation and invasion, and advanced apoptosis	Increasing	Adriamycin	[212]
miR-17	Upregulated	EMT, DEDD	Inhibit apoptosis	Decreasing	Cisplatin, 5-Fluorouracil	[213]
miR-17-5p	Downregulated	P21	Inhibit apoptosis	Decreasing	Cisplatin	[214]
mir-15b or miR-16	Downregulated	Bcl-2	Induce apoptosis	Increasing	Doxorubicin, Etoposide, Vincristine, Cisplatin	[215]
miR-19a/b	Upregulated	PI3K-Akt/ PTEN	Accelerate drug efflux and inhibit apoptosis	Decreasing	Cisplatin, 5-Fluorouracil, Adriamycin	[216]
miR-20a	Upregulated	NFκB/CYLD	Inhibit apoptosis	Decreasing	Cisplatin	[217]
miR-20a	-	PI3K-AKT and MAPK-ERK/ LRIG1	Reduce apoptosis	Decreasing	Adriamycin, Vincristine	[218]
miR-21	Upregulated	PTEN-PI3K-Akt/PTEN	Reduce antiproliferative effects and apoptosis	Decreasing	Cisplatin	[219]
miR-23b-3p	Downregulated	ATG12 and HMGB2	Inhibit autophagy	Increasing	Vincristine, 5-Fluorouracil and Cisplatin	[220]
miR-25	Upregulated	FOXO3a	Promote GC cycle progression	Decreasing	Cisplatin	[221]
miR-27a and miR-155	Upregulated	RKIP	Inhibit apoptosis	Decreasing	5-Fluorouracil and Oxaliplatin	[209]
miR-30a	Upregulated	beclin 1	Suppress autophagy, induce apoptosis and G2/M cell cycle arrest	Increasing	Cisplatin	[222]
miR-31	Downregulated	RhoA	Enhance apoptosis, inhibit cell cycle	Increasing	5-Fluorouracil	[223]
miR-34	-	Bcl-2, Notch, and HMGA2	Induce GC apoptosis, Caspase-3 activation, and accumulate in G1 phase	Increasing	Docetaxel, Gemcitabine, Cisplatin, Doxorubicin	[224]
miR-34a	Upregulated	MET	Inhibit GC proliferation and induct apoptosis	Increasing	Cisplatin	[225]
miR-34c	Downregulated		Promote GC apoptosis and inhibit proliferation	Increasing	Paclitaxel, Cisplatin	[226]
miR-34c-5p	Downregulated	MAPT	Regulate DNA methylation, inhibit GC proliferation and promote apoptosis	Increasing	Paclitaxel	[227]
miR-96	Upregulated	FOXO1	Promote GC proliferation	Decreasing	Cisplatin, Doxorubicin	[228]
miR-99a and miR-491	Upregulated	AKT-FOX3A/ CAPNS1	Induced GC apoptosis	Increasing	Cisplatin	[229]
miR-101	Downregulated	p38MAPK and AKT / ANXA2	Promote GC apoptosis	Increasing	Cisplatin, Vincristine	[230]
miR-106a	Upregulated	RUNX3	Accelerate ADR efflux, and suppress apoptosis	Decreasing	Adriamycin, Vincristine	[231]
miR-106a	Upregulated	PI3K-AKT/ PTEN	Regulate GC apoptosis	Decreasing	Cisplatin	[232]
miR-126	Downregulated	EZH2	Promote GC proliferation and migration	Increasing	Vincristine, Adriamycin	[233]
miR-128	Downregulated	HMGA2	Increase GC apoptosis	Decreasing	Cisplatin	[234]
miR-129	Downregulated	P-gp	Activate apoptotic pathway via upregulating caspase-9 and caspase-3	Increasing	Cisplatin	[235]
miR-130b	Upregulated	CMPK1	Reduce sensitivity and DNA damage	Increasing	5-Fluorouracil	[236]
miR-132	Upregulated	SIRT1-CREB-ABCG2/ SIRT1	Regulate CSC	Decreasing	Cisplatin	[237]
miR-135a-5p	Upregulated	AP-2α/ BCL-2	Enhance cell resistance to apoptosis	Increasing	Adriamycin	[238]
miR-135b	Upregulated	MAPK/ MST1	Inhibit apoptosis, and induce proliferation	Decreasing	Cisplatin	[239]
miR-145	Downregulated	CD44	Regulate CSC	Decreasing	5-Fluorouracil, Cisplatin	[240]
miR-148a-3p	Downregulated	AKAP1, RAB12	Activate mitochondrial fission and apoptosis	Increasing	Cisplatin	[241]
miR‑138‑5p	Downregulated	ERCC	Regulate DNA damage repair	Increasing	Cisplatin	[242]
miR-155	Upregulated	STAT3 and NF-κB	Inhibit GC apoptosis, promote proliferation	Decreasing	Cisplatin and 5-Fluorouracil	[243]
miR-155-5p	Upregulated	GATA3 TP53INP1	Regulate EMT	Decreasing	Paclitaxel	[244]
miR-181a	Upregulated	MTMR3	Attenuate GC apoptosis and autophagy	Decreasing	Cisplatin	[245]
miR-181a-2-3p	Upregulated		Inhibit GC apoptosis	Increasing	Cisplatin	[246]
miR-181b	Downregulated	BCL2	Induce apoptosis	Increasing	Vincristine, Cisplatin, Adriamycin, Etoposide, 5-Fluorouracil	[247]
miR-185	Upregulated	ARC	Induce apoptosis	Increasing	Cisplatin, Doxorubicin	[248]
miR-193a-3p	Upregulated	Mitochondrial apoptosis/ SRSF2	Inhibit apoptosis	Decreasing	Cisplatin	[249]
miR‑195‑5p	Downregulated	ZNF139	Regulate MDR	Increasing	5-Fluorouracil, Oxaliplatin	[250]
miR-200bc/429	Downregulated	BCL2, XIAP	Induce apoptosis	Increasing	Vincristine, Cisplatin, Adriamycin, Etoposide, 5-Fluorouracil	[251]
miR-200c	Downregulated	Zinc finger E-box binding homeobox 2	Induce apoptosis	Increasing	Cisplatin	[252]
miR-204	Downregulated	Bcl-2	Promote GC apoptosis	Increasing	5-Fluorouracil; Oxaliplatin	[253]
miR-204	Downregulated	TGFBR2	Regulate EMT	Increasing	5-Fluorouracil	[254]
miR-218	Upregulated	mTOR	Induce apoptosis	Increasing	Cisplatin	[255]
miR-223	Upregulated	FBXW7	Regulate cell cycle and apoptosis	Decreasing	Cisplatin	[256]
miR-223	Upregulated	FBXW7	Regulate EMT	Decreasing	Doxorubicin	[257]
miR-193-3p	Upregulated	PTEN	Promote GC proliferation migration	Decreasing	5Ffluorouracil	[258]
miR-301b-3p	Upregulated	TXNIP	Promote MDR	Decreasing	Cisplatin, Vincristine	[259]
miR-361-5p	-	PI3K-AKT-mTOR/ FOXM1	Inhibit autophagy	Increasing	Docetaxel	[260]
miR-363	Upregulated	FBW7	Promote GC proliferation	Decreasing	docetaxel + cisplatin + 5-FU	[261]
miR-375	Upregulated	PI3K-AKT/ ERBB2	Anti-proliferative and apoptosis-inducing	Increasing	Cisplatin	[262]
miR-421	Upregulated	E-cadherin and caspase-3	Promote metastasis, inhibit apoptosis	Decreasing	Cisplatin	[53]
miR-424-3p	Downregulated	ABCC2	Promote GC proliferation	Decreasing	Cisplatin	[263]
miR-429	Downregulated	PI3K-AKT-mTOR/ SOX2	Inhibit apoptosis	Decreasing	Cisplatin	[264]
miR-492	Upregulated	DNMT3B	Induce GC proliferation	Decreasing	Cisplatin	[265]
miR-493		MAD2L1	Regulate chemosensitivity	Decreasing	Paclitaxel	[266]
miR-495-3p	Downregulated	GRP78-mTOR/ GRP78	Inhibit autophagy	Increasing	Vincristine, Adriamycin	[267]
miR-497	Upregulated	Bcl-2	Induce apoptosis	Increasing	Vincristine; Cisplatin; Etoposide; Adriamycin	[268]
miR-500a-3p	Upregulated	FBXW7	Induce CSCs properties	Decreasing	Cisplatin	[269]
miR-503	Downregulated	IGF1R, BCL2	Inhibit GC proliferation, induce apoptosis	Increasing	Cisplatin	[270]
miR-508-5p	Downregulated	ZNRD1,ABCB1	Induce apoptosis	Increasing	Vincristine; Adriamycin; 5-Fluorouracil; Cisplatin	[271]
miR-524-5p	Upregulated	SOX9	Inhibit GC proliferation and invasion	Increasing	Cisplatin	[272]
miR-590-5p	Upregulated	AKT-ERK and STAT3/ RECK	Promote GC proliferation and invasion	Decreasing	Cisplatin and Paclitaxel	[273]
miR-623	Downregulated	Cyclin D1	Inhibit GC proliferation	Increasing	5-Fluorouracil	[274]
miR-647	Downregulated	ANK2-CD44-SNAIL1/ Ankyrins	Induce GC apoptosis and prevent cells from entering S phase of the cell cycle	Increasing	Vincristine	[275]
miR-648	Downregulated	ET-1	Induct apoptosis	Increasing	5-Fluorouracil	[276]
miR-708-3p	Upregulated	ETNK1	Promote GC proliferation and migration, inhibit apoptosis, and facilitate the transition from the G0/G1 to the G2/M phase	Decreasing		[277]
miR-873-5p	Downregulated	THUMPD1	Regulate migration, invasion, and chemoresistance	Increasing	Doxorubicin, 5-Fluorouracil, Cisplatin	[278]
miR-874	Downregulated	ATG16L1	Inhibit autophagy	Increasing	Cisplatin	[279]
miR-1229-3p	Upregulated	SLC22A7	Induce chemoresistance	Decreasing	5-Fluorouracil	[280]
miR-1284	Downregulated	EIF4A1-JUN-MYC/ EIF4F	Promote cell cycle arrested at the G0/G1 phase, induce apoptosis	Increasing	Vincristine	[281]
miR-4295	Upregulated	EGFR-PI3K-AKT/ LRIG1	Induce apoptosis	Decreasing	Cisplatin	[282]

Abbreviations: miRNAs MicroRNAs, GC Gastric cancer

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