Fig. 1
From: Implications of PD-L1 expression on the immune microenvironment in HER2-positive gastric cancer
Study design and the spatial immune features of HER2-positive gastric cancer. a The illustration of cohorts, including the clinical cohort, the single-cell RNA sequencing cohort, and the multiplex immunohistochemistry cohort. b Survival analysis of irPFS and irOS between the treatment regimen of anti-HER2 plus chemotherapy and anti-HE2 therapy plus immunotherapy in HER2-positive gastric cancer with CPS < 1 (Log-rank test). c Multiplex immunohistochemical staining labels 21 markers through 5 panels. d The illustration of the method for calculating the effective score, which quantifies the extent to which central tumor cells are surrounded by peripheral immune cells. (e-i) Comparisons of spatially efficient scores among different immune cells and their respective functional subtypes. Abbreviations: HER2, human epidermal growth factor receptor 2; CPS, combined positive score; FFPE, formalin-fixed paraffin-embedded