Table 1 Extracellular vesicles mediate ovarian cancer metastasis
EV source | EV type | EV cargo | Mechanism | Function | Refs |
|---|---|---|---|---|---|
Serum of EOC patients | Exosome | LRP1 | Via p-ERK/MMP2/MMP9 pathway | Promote migration and invasion | Zhou W et al. |
M2 macrophages | Exosome | miR-221-3p | Target CDKN1B | Promote migration and invasion | Li X et al. |
OC cell lines | EV | miR-106a-5p | Target KLF6 | Promote proliferation, invasion and migration | Zheng Y et al. |
TWEAK-stimulated macrophages | Exosome | miR-7 | Inhibit the EGFR/AKT/ERK1/2 pathway | Inhibit invasion | Hu Y et al. |
OC cell lines | EV | circATP2B4 | Via miR-532-3p/SREBF1/PI3Kα/AKT axis | Promote M2 Macrophage Polarization | Wang F et al. |
OC cell lines | EV | miR-181c-5p | Via KAT2B/HOXA10 axis and activate the JAK1/STAT3 pathway | Promote M2 Macrophage Polarization | Yang S et al. |
OC cell lines | Exosome | miR-141 | Activate the YAP1/GROα/CXCR pathway | Form tumor-promoting stromal niche | Mo Y et al. |
OC cell lines | EV | miR-630 | Inhibit KLF6 and activate NF-κB | Promote activation of CAFs | Cui Y et al. |
Ascites of OC patients and OC cell lines | EV | LncRNA SPOCD1-AS | Interact with G3BP1 | Remodel mesothelial cells | Wang C et al. |
OC cell lines | Exosome | ANXA2 | Via PI3K/AKT/mTOR pathway | Regulate epithelial-mesenchymal plasticity of peritoneal mesothelial cells | Gao L et al. |
OC cell lines | Exosome | circPUM1 | Up-regulate NF-κB and MMP2 | Promote MMT of peritoneal mesothelial cells | Guan X et al. |
OC cell lines | Exosome | miR-99a-5p | Increase fibronectin and vitronectin expression | Regulate peritoneal mesothelial cells | Yoshimura A et al. |
OC cell lines | Exosome | ETS1 | Via integrin αvβ5/AKT/Sp1 pathway | Regulate peritoneal mesothelial cells | Li H et al. |
Omental CAFs | Exosome | miR-29c-3p | Target MMP2 | Suppress OC cells invasion | Han Q et al. |
OC cell lines | Exosome | miR-205 | Via PTEN-AKT pathway | Induce angiogenesis | He L et al. |
OC cell lines | sEV | miR-141-3p | Activate the JAK/STAT3 and NF-κB pathways | Promote endothelial cell angiogenesis | Masoumi-Dehghi S et al. |
OC cell lines | Exosome | E-cadherin | Activate the β-catenin and NF-κB pathway | Promote tumor angiogenesis | Tang MKS et al. |
MSCs | EV | miR-424 | Down-regulate MYB | Inhibit angiogenesis | Li P et al. |
OC cell lines | EV | Phosphatidyl- serine | Arrest the T-cell signaling cascade | Inhibit T-cell function | Kelleher RJ Jr et al. |
OC cell lines | sEV | Arginase-1 | Suppress T-cell responses | Mitigate anti-tumor immune responses | Czystowska-Kuzmicz M et al. |
M2-polarized TAMs | EV | NEAT1 | Via miR-101-3p/ZEB1/PD-L1 axis | Promote CD8 + T cells apoptosis | Yin L et al. |
TAMs | Exosome | miR-29a-3p, miR-21-5p | Target STAT3 | Induce a Treg/Th17 cell imbalance | Zhou J et al. |
CAFs | Exosome | circ IFNGR2 | Via miR-378/ST5 axis | Inhibit EMT of OC cells | Chen X et al. |