Unraveling the extracellular vesicle network: insights into ovarian cancer metastasis and chemoresistance

Table 2 Extracellular vesicles regulate ovarian cancer drug resistance

EV source	EV type	EV cargo	Mechanism	Function	Refs
OC cell lines	Exosome	miR-1246	Via Cav1/p-gp/M2-type macrophage axis	Confer chemoresistance	Kanlikilicer P et al.
OC cell lines	Exosome	miR-429	Target CASR via NF-κB	Confer chemoresistance	Li T et al.
OC cell lines	Exosome	miR-21-3p	Target NAV3	Increase resistance to cisplatin	Pink RC et al.
OC cell lines	Exosome	miR-21-5p	Target PDHA1	Inhibit chemosensitivity	Zhuang L et al.
OC cell lines	Exosome	pGSN	Interact with HIF1α	Enhance chemoresistance	Asare-Werehene M et al.
OC cell lines	sEV	pGSN	Regulate GSH	Enhance chemoresistance	Asare-Werehene M et al.
Macrophages	Exosome	miR-223	Via PTEN-PI3K/AKT pathway	Elicit a chemoresistant phenotype	Zhu X et al.
TAMs	EV	GATA3	Up-regulate the CD24/Siglec-10 axis	Enhance chemoresistance	Chen C et al.
CAFs	Exosome	miR-98-5p	Down-regulate CDKN1A	Promote cisplatin resistance	Guo H et al.
OC cell lines	Exosome	miR497, TP	Use exosome-liposome hybrid nanoparticles	Overcome chemoresistance	Li L et al.
Mature bovine milk	Exosome	Cisplatin	Evade the endosome trapping	Enhance delivery of cisplatin	Zhou G et al.
MSCs	EV	miR-18a-5p	Target NACC1 and activate the AKT/mTOR pathway	Promote cisplatin sensitivity	Wang X et al.
hUCMSCs	Exosome	miR-146a	Via LAMC2-mediated PI3K/Akt axis	Promote docetaxel and taxane sensitivity	Qiu L et al.

pGSN, plasma gelsolin; GSH, glutathione; TP, triptolide; UC, umbilical cord; hUCMSC, human umbilical cord mesenchymal stem cell; Ex-pGSN, exosome-transported pGSN.

ISSN: 1476-4598