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Fig. 2 | Molecular Cancer

Fig. 2

From: Cancer therapy resistance mediated by cancer-associated fibroblast-derived extracellular vesicles: biological mechanisms to clinical significance and implications

Fig. 2

CAF-derived EVs in cancer chemotherapy resistance. The detailed biological mechanisms of CAF-derived EVs in mediating cancer chemoresistance are summarized. CAF-derived EVs can deliver miRNAs, lncRNAs, circRNAs and proteins to mediate cancer chemotherapy resistance by regulating cell cycle, DNA repair, oxidative stress, EMT, apoptosis, autophagy, cancer cell stemness, angiogenesis, immune cells infiltration and various signalling pathways including PI3K/AKT, Wnt/β-catenin, and PTEN/mTOR pathways

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Molecular Cancer

ISSN: 1476-4598