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Fig. 3 | Molecular Cancer

Fig. 3

From: Cancer therapy resistance mediated by cancer-associated fibroblast-derived extracellular vesicles: biological mechanisms to clinical significance and implications

Fig. 3

CAF-derived EVs mediate cancer therapy resistance through complex mechanisms. CAF-derived EVs can deliver multiple cargoes to tumour cells, including miRNAs, lncRNAs, circRNAs and proteins. They can mediate the resistance to chemotherapy, targeted therapy, radiotherapy, and immunotherapy through multiple biological mechanisms, such as regulation of autophagy, EMT, and cancer stemness, metabolism, angiogenesis, DNA repair, immune infiltration, cell cycle, transcription and oncogenic signalling pathways

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Molecular Cancer

ISSN: 1476-4598