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Table 2 CAF-derived EVs in cancer radiotherapy resistance

From: Cancer therapy resistance mediated by cancer-associated fibroblast-derived extracellular vesicles: biological mechanisms to clinical significance and implications

Key cargo

Cancer type

Genes and pathways or biological processes

Radioresistance

Ref

miR-143-3p

ESCC

M2 macrophage polarization

↑

[94]

miR-590-3p

CRC

PI3K and AKT

↑

[96]

miR-93-5p

CRC

FOXA1 and TGFB3

↑

[97]

miR-196a-5p

LC

NFKBIA and NF-κB

↑

[98]

lncRNA AFAP1-AS1

ESCC

DNA repairment

↑

[99]