Fig. 2

N2-polarized neutrophils derived exosomes promote gastric cancer metastasis in vivo. (A) Flow chart of the procedure for evaluating the effects of N2-Exo on cancer metastasis in mouse tumor models. (B) The signal intensities of bioluminescent imaging in the lung tissues of indicated groups. (C) Lung tissues with metastatic nodules in the indicated groups. (D) H&E staining of lung tissues in the indicated groups. Top panel, scale bars, 1 mm. Bottom panel, scale bars, 100 μm. (E) The number of metastatic nodules in the lung tissues of indicated groups. (F) The survival time of mice in the indicated groups. (G) Schematic design for N2-Exo treatment in abdominal implantation tumor model. (H) The signal intensities of bioluminescent imaging in the peritoneum of indicated groups. (I) Intestine tissues with metastatic nodules in the indicated groups. (J) The number of metastatic nodules in the intestine tissues of indicated groups. *P < 0.05 and **P < 0.01