Fig. 1

A concise overview of the spatial and temporal distribution of high-quality research hotspots in the AlphaFold domain. (A) Machine learning-based unsupervised clustering algorithm divides global research hotspots into six major clusters; (B) Time series tracking reveals the global temporal distribution pattern of research hotspots; (C) Spatial density network graph visualizes the total link strength (TLS) of global research hotspots (D) Spatial density network graph visualizes the occurrence frequency (OF) of global research hotspots