Fig. 2

Survival Analysis Demonstrating the Prognostic Value of the 5-Gene Signature. A: Kaplan-Meiercurves for progression-free survival (PFS) in the PMBCR cohort, revealing a significant survival benefit for patientspredicted as responders by the 5-gene signature compared to predicted non-responders (P < 0.001). B: Kaplan-Meier curves for PFS in the prospective PBMCP cohort, confirming the prognostic value of the 5-gene signature,with predicted responders exhibiting significantly longer PFS than predicted non-responders (P < 0.001). C: Kaplan-Meier curves for PFS in the BC cohort, demonstrating a significant survival advantage for predicted respondersover predicted non-responders based on the 5-gene signature (P < 0.001). D: Kaplan-Meier curves for overallsurvival (OS) in the BC cohort, showing a significant survival benefit for patients predicted as responders by the 5-gene signature compared to predicted non-responders (P < 0.001)