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Fig. 2 | Molecular Cancer

Fig. 2

From: Chimeric antigen receptor macrophages targeting c-MET(CAR-M-c-MET) inhibit pancreatic cancer progression and improve cytotoxic chemotherapeutic efficacy

Fig. 2

A Schematic diagram of the CAR structure and CAR THP-1 construction, induction, phagocytosis, and killing effect. B Purification of CAR THP-1 by FCM sorting. C FCM showed that CAR THP-1 could effectively bind His-tag hu-c-MET recombinant protein. D CAR THP-1 or NC THP-1 was co-cultured with BxPC-3 mcherry + at a ratio of 5:1, and the co-culture system was detected by FCM at 30 min, 2 h, 4 h, and 6 h. E CAR THP-1 or NC THP-1 was co-cultured with BxPC-3 mcherry + at a ratio of 10:1 for 24 h, and residual BxPC-3 mcherry + cells were detected by FCM. F CAR THP-1 or NC THP-1 was co-cultured with BxPC-3 mcherry + at a ratio of 5:1 for 24 h; residual BxPC-3 mcherry + cells were detected by FCM

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Molecular Cancer

ISSN: 1476-4598