Skip to main content
Fig. 6 | Molecular Cancer

Fig. 6

From: Chimeric antigen receptor macrophages targeting c-MET(CAR-M-c-MET) inhibit pancreatic cancer progression and improve cytotoxic chemotherapeutic efficacy

Fig. 6

A Flow chart of establishment of orthotopic pancreatic transplantation tumor model in NOD/SCID mice and verification of anti-tumor effect of CAR THP-1 i.p. B Survival curves of orthotopic pancreatic transplantation tumor model. C Bioluminescence image of orthotopic pancreatic transplantation tumor model. D Quantitative analysis and t-test of tumor burden on the last bioluminescence images of orthotopic pancreatic transplantation tumor model. E HE staining of tumor tissue. F TUNEL detection of tumor tissues. G HE staining of liver (micrometastasis), lung, stomach, intestine, kidney and heart. (H) CAR THP-1 luci + or NC THP-1 luci + cells were intraperitoneally injected into orthotopically tumor-bearing mice and healthy mice, and the biodistribution of THP-1 cells was detected by bioluminescence. I CAR THP-1 luci + /NC THP-1 luci + cells were intraperitoneally injected into orthotopically tumor-bearing mice and healthy mice for 5 days, and the distribution of THP-1 cells in various vital organs of mice was detected by bioluminescence (*, p < 0.05)

Back to article page

Molecular Cancer

ISSN: 1476-4598