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Fig. 3 | Molecular Cancer

Fig. 3

From: Single-cell RNA sequencing identifies molecular biomarkers predicting late progression to CDK4/6 inhibition in patients with HR+/HER2- metastatic breast cancer

Fig. 3

Analysis of major non-tumor cell subtypes. A UMAP plot of major non-tumor cells stratified by different sample statuses (BL, EP, and LP). B Dot plot showing the marker gene expression for each major non-tumor cell type in (A). C Bar plot showing the relative fractions of major non-tumor cell types for each sample. The color legend is the same as in panel (A). D Cell fraction frequency of major non-tumor cell types across sample statuses (BL, EP, and LP). E MP analysis heatmap showing the median module score difference from samples with pooled T cells. F Ligand-receptor (L-R) interaction analysis using CellChat in samples from BL, EP, and LP. The red box indicates the SPP1-CD44 or ITGA4 interactions, while the green box indicates the MDK-NCL, MDK-syndecan, or LGALS9 interactions. *, p < 0.05

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Molecular Cancer

ISSN: 1476-4598