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Fig. 4 | Molecular Cancer

Fig. 4

From: Single-cell RNA sequencing identifies molecular biomarkers predicting late progression to CDK4/6 inhibition in patients with HR+/HER2- metastatic breast cancer

Fig. 4

CD4+ T and CD8+ T cell functional analysis. A t-Distributed stochastic neighbor embedding (t-SNE) plot of 13 different subtypes of T cells in the embedding space. B Dot plot showing the marker gene expression of each T cell subtype in (A). C Bar plot showing the relative fraction of each T cell subtype for each sample, stratified by different sample statuses (BL, EP, and LP). D Cell fraction of CD4+ and CD8+ T cell subtypes in BL, EP, and LP samples. E Heatmap displaying expression of 14 curated gene signatures across CD4+ T cell clusters. Violin plots show significantly differentially expressed stress genes of (F) HSP90AA, (G) HSP90AB, and (H) HSPA8 across different groups for CD4+ T cells. I Heatmap displaying expression of 14 curated gene signatures across CD8+ T cell clusters. Violin plots showing that (J) HSP90AA, (K) HSP90AB, and (L) HSPA8 were significantly differentially expressed across different groups for CD8.+ T cells. M Dot plot showing the expression of exhaustive gene signatures across different groups. *, p < 0.05; **, p < 0.01; ***, p < 0.001; ****, p < 0.0001

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Molecular Cancer

ISSN: 1476-4598