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Fig. 5 | Molecular Cancer

Fig. 5

From: Single-cell RNA sequencing identifies molecular biomarkers predicting late progression to CDK4/6 inhibition in patients with HR+/HER2- metastatic breast cancer

Fig. 5

Other non-tumor cells atlas. A UMAP plot of NK cells stratified by 3 different NK subtypes. B Comparison of NK cell subtype fractions among BL, EP, and LP samples. C Dot plot showing the marker gene expression of each NK cell subtype in (A). D Heatmaps of module score differences from samples with NK cells, M1 macrophages, M2 macrophages, and B cells. (E) UMAP plot of myeloid cells stratified by 5 different cell subtypes. F Comparison of macrophage cell subtype fractions among BL, EP, and LP samples. G Comparison of DC subtype fractions among BL, EP, and LP samples. H UMAP plot of annotated myeloid cells stratified by BL, EP, and LP samples. I Dot plot showing the marker gene expression for each myeloid cell subtype in (D). J Module score analysis of M1 macrophages among BL, EP, and LP samples. K Module score analysis of M2 macrophages between BL, EP, and LP samples. *, p < 0.05

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Molecular Cancer

ISSN: 1476-4598