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Table 1 AUROC of baseline BCL-2 dependence for the prediction of treatment response and outcome

From: BCL-2 dependence is a favorable predictive marker of response to therapy for chronic lymphocytic leukemia

FEATURE

AUROC (VALUE)

AUROC

(SD)

TREATMENT TIMEPOINT

RESPONSE (AREA)

ABT199 (1 μM)

0.802

0.082

Post Cycle 3

MRD PB

ABT199 (1 μM)

0.783

0.117

Post FCR

MRD PB

ABT199 (0.1 μM)

0.773

0.118

Post FCR

MRD PB

BAD (0.1 μM)

0.760

0.112

Post FCR

MRD PB

ABT199 (0.5 μM)

0.752

0.133

Post FCR

MRD PB

  1. Post Cycle 3: Halfway through combination therapy
  2. Post FCR: End of combination therapy
  3. MRD PB: Minimal Residue Disease Peripheral Blood