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Fig. 6 | Molecular Cancer

Fig. 6

From: Modulating lipid metabolism by nanoparticles (NPs)-mediated ACSL3 silencing to inhibit hepatocellular carcinoma growth and metastasis

Fig. 6

NPs-mediated ACSL3 silencing inhibits the proliferation, migration, and invasion of HCC cells. (A) Schematic illustration of the endosomal pH-responsive nanoplatform made with the polymer Meo-PEG-b-PDPA and cationic lipid-like compound G0-C14. (B, C) Size distribution (B) and morphology (C) of the NPs(siACSL3) in aqueous solution. (D) Cumulative siACSL3 release from the NPs(siACSL3) in aqueous solution at pH 7.4 or 6.0. (E, F) qRT-PCR (E) and western blot (F) analysis of ACSL3 expression in MHCC-97H cells treated with the NPs(siACSL3) at different siACSL3 concentrations. (G) Proliferation of MHCC-97H cells treated with naked siACSL3, NPs(siCTL), or NPs(siACSL3) at a siRNA concentration of 30 nM. The cells incubated in blank culture medium were used as Control. (H) Clone formation, migration, invasion, anoikis, and the statistic results of MHCC-97H cells treated with the formulas shown in (G). ns, no significance; * p < 0.05; *** p < 0.001

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Molecular Cancer

ISSN: 1476-4598