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Fig. 7 | Molecular Cancer

Fig. 7

From: Modulating lipid metabolism by nanoparticles (NPs)-mediated ACSL3 silencing to inhibit hepatocellular carcinoma growth and metastasis

Fig. 7

NPs-mediated ACSL3 silencing inhibits HCC growth and metastasis in MHCC-97H orthotopic tumor model. (A) Blood circulation profile of naked siACSL3 and NPs(siACSL3). (B, C) Overlaid fluorescence image of the tumors and main organs (B) and biodistribution of naked siACSL3 and NPs(siACSL3) in MHCC-97H xenograft tumor-bearing mice sacrificed at 24 h post injection (C). (D, E) Bioluminescence images (D) and survival rate (E) of MHCC-97H orthotopic tumor-bearing mice treated with PBS, naked siACSL3, NPs(siCTL), or NPs(siACSL3). (F, G) Histological staining (F) and statistic results of metastatic nodes in the lung tissues (G) of MHCC-97H orthotopic tumor-bearing mice after systemic treatment in each group. (H) Expression of ACSL3, TUNEL, Ki67 and the statistical results determined by IHC staining analysis of the tumor tissues of mice after systemic treatment in each group. ns, no significance; *** p < 0.001

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Molecular Cancer

ISSN: 1476-4598