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Fig. 8 | Molecular Cancer

Fig. 8

From: Modulating lipid metabolism by nanoparticles (NPs)-mediated ACSL3 silencing to inhibit hepatocellular carcinoma growth and metastasis

Fig. 8

NPs-mediated ACSL3 silencing inhibits HCC growth in PDX tumor model. (A) Schematic illustration of PDX tumor inoculation and treatment of PDX tumor-bearing mice. 21 days after tumor inoculation, tumor-bearing mice were treated with PBS, naked siACSL3, NPs(siCTL), or NPs(siACSL3). (B-D) Tumor growth (B), tumor weight (C), and the image of collected tumors (D) of PDX tumor-bearing mice treated with the formulas shown in (A). (E) Expression of ACSL3, TUNEL, Ki67 and the statistical results determined by IHC staining analysis of the tumor tissues of mice after systemic treatment in each group. ns, no significance; *** p < 0.001

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Molecular Cancer

ISSN: 1476-4598