Fig. 6
From: Understanding gold nanoparticles and their attributes in ovarian cancer therapy
(a) Graphical representation of treatment of ovarian cancer cells under the influence of ultrasonic waves and Au NPs. (b and c) ICP-MS analysis on A2780 cis ovarian cells showing higher accumulation of Pt ion via triple combination therapy. Under the influence of Au NPs, cis got accumulated. (d, e and f) The US, Au NPs and Cis triple combination treatment effectively inhibited each cell’s capacity to form colonies, and our findings demonstrated that the with low dosage drug concentrations, triple combination therapy exhibited a long-term therapeutic impact on resistant cells, suppressing about 83% of colony growth. (g, h and i) The triple combination therapy has same effect on 2D and 3D model of drug resistant ovarian cancer spheroid. Statistically, 10% more spheroid was treated with combination treatment as compared to US and Cis alone [129]