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Fig. 1 | Molecular Cancer

Fig. 1

From: DNA damage response signatures are associated with frontline chemotherapy response and routes of tumor evolution in extensive stage small cell lung cancer

Fig. 1

SCLC clusters into three distinct DDR clusters with unique molecular features. A MD Anderson GEMINI optimal number of k clusters elbow plot and DDR cluster heatmap. B Optimal number of k clusters elbow plot and DDR cluster heatmap for the IMpower133 cohort. C IMpower133 DDR cluster differential gene expression and quantitative set analysis (QuSAGE) hallmark pathway results. D GEMINI DDR cluster DNA damage responsive transcription factor expression. E GEMINI DDR cluster intra-S and G2/M cell cycle checkpoint machinery expression. F Expression of DNA damage responsive transcription factors in IMpower133 DDR clusters. G. Expression of intra-S and G2/M cell cycle checkpoint machinery in IMpower133 DDR clusters. H-I GEMINI and IMpower133 DDR cluster RepStress scores. A-B NHEJ: Non-homologous end-joining. TLS: Translesion synthesis. NER: Nucleotide excision repair. MMEJ: Microhomology mediated end-joining. HR: Homologous recombination. FA: Fanconi Anemia. Checkpoint: Damage sensing and signaling. MMR: Mismatch repair. BER: Base excision repair. DR: Direct reversal repair

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Molecular Cancer

ISSN: 1476-4598