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Fig. 4 | Molecular Cancer

Fig. 4

From: DNA damage response signatures are associated with frontline chemotherapy response and routes of tumor evolution in extensive stage small cell lung cancer

Fig. 4

DDR status identifies a spectrum of “inflamed” features both within and across SCLC subtypes. A GEMINI DDR cluster ESTIMATE Immune and Stromal scores. B IMpower133 DDR cluster Immune and Stromal scores. C IMpower133 SCLC-A only DDR cluster Immune and Stromal scores. D IMpower133 SCLC-A only DDR cluster MHC Class I gene expression. E IMpower133 SCLC-A DDR cluster pro-inflammatory cytokine and immune suppressive checkpoint effector gene expression. F SCLC cell line DDR cluster Antigen Presenting Machinery scores. G SCLC cell line DDR cluster MHC Class I gene expression. H SCLC cell line DDR cluster B2M and CIITA gene expression. I. SCLC cell line DDR cluster cGAS and STING1 gene expression. J SCLC cell line DDR cluster cGAS, STING1, and PDL1 protein expression. K SCLC cell line DDR cluster LSD1 and EZH2 protein expression. L. SCLC/hgNEC PDX/CDX DDR cluster single cell RNAseq STING1 binary expression plots. M SCLC/hgNEC PDX/CDX DDR scRNAseq STING1 binary expression summary plot

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Molecular Cancer

ISSN: 1476-4598