Fig. 1

This figure illustrates the role of the APC gene within the Wnt signaling pathway and its significance as a cancer biomarker. It begins by depicting the normal Wnt signaling process, highlighting the sequential activation of Wnt ligands, receptors, and the downstream destruction complex. A key focus is on the APC destruction complex, showing its role in regulating β-catenin levels under normal conditions. The figure also demonstrates how APC gene mutations disrupt this complex, leading to the abnormal accumulation of β-catenin, a critical event in cancer initiation and progression