Fig. 3

This figure illustrates the toxicity and management strategies associated with Wnt-directed therapies in cancer treatment. It highlights the Wnt signaling pathway, emphasizing key components such as Wnt ligands, Frizzled receptors, β-catenin, and TCF/LEF, which play crucial roles in cancer progression. Various Wnt-directed therapies are shown, including Wnt inhibitors, β-catenin inhibitors, tankyrase inhibitors, and monoclonal antibodies targeting Wnt receptors. The toxicity profile of these therapies is outlined, detailing both acute and chronic side effects, such as gastrointestinal issues, hematological toxicity, liver toxicity, and their impact on stem cell populations. Management strategies are categorized into pre-therapy, during therapy, and post-therapy phases