Fig. 2

Roles of signaling networks downstream of SLAMF receptors in regulating immune cells. The homophilic interaction of SLAMF receptors between immune cells and target cells will trigger a cascade of downstream protein activation. Most signaling transmitted by SLAMF receptors needs the involvement of the SAP adaptor family having an SH2 domain, like SAP, EAT-2, and ERT. In contrast, some SLAMF receptors transmit signals in the SAP adaptors-independent manner but recruit inhibitory phosphatases containing the SH2 domain, such as SHIP, SHP-1, and SHP-2. Finally, these signaling pathways downstream of SLAMF receptors play different roles in regulating immune cells. However, the specific mechanisms of some roles are still unclear. The graph on the left shows the SAP-dependent signaling pathway of SLAMF receptors and their corresponding roles. The graph in the middle shows the SAP adaptors-independent signaling networks and their roles in regulating immune cells. The graph on the right shows the EAT-2-dependent signaling pathway of SLAMF receptors and their corresponding roles. Abbreviation: SAP, SLAMF-associated protein; EAT-2, Ewing’s sarcoma-associated transcript-2; ERT, EAT-2 related transducer; Th2, T helper 2; PKCθ, protein kinase C-theta; NF-κB, nuclear factor-kappa B; IFN-γ, interferon γ; Ca, calcium; c-CBL, c-Casitas B-lineage lymphoma; PLC-γ, phospholipase C gamma; Erk, extracellular signal-related kinase; SHIP, SH2-domain-containing inositol-5-phosphatase; SHP, SH2 domain-containing protein tyrosine phosphatases; Csk, C-terminal Src kinase. The figure is created with BioRender.com