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Fig. 3 | Molecular Cancer

Fig. 3

From: Perioperative nivolumab and chemotherapy in locally advanced squamous cell carcinoma of the oesophagus: a randomized multicentre phase 2 study with circulating tumor DNA dynamics monitoring

Fig. 3

Overview of the ctDNA analysis design and baseline ctDNA status. (A) Flow diagram of the ctDNA analysis design. (B) Genomic profile of the top 30 mutated genes for OSCC from the WES data. (C) Pie chart of the proportion of selected variants in personalized panels that were shared by patients. (D) Scatter plot between primary tumor size and baseline ctDNA fraction calculated by Spearman correlation (R = 0.29, P = 0.029). (E) Violin plot of the baseline ctDNA fraction for different pre-treatment clinical stage of tumor. (P = 0.52, Wilcoxon test). (F) Violin plot of the baseline ctDNA fraction for different operation pCR status. (P = 0.74, Wilcoxon test). (G) Violin plot of the baseline ctDNA fraction for different TRG stages. (P = 0.43, Kruskal-Wallis test)

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Molecular Cancer

ISSN: 1476-4598