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Fig. 4 | Molecular Cancer

Fig. 4

From: Perioperative nivolumab and chemotherapy in locally advanced squamous cell carcinoma of the oesophagus: a randomized multicentre phase 2 study with circulating tumor DNA dynamics monitoring

Fig. 4

Preoperative ctDNA status correlates with tumor regression and prognosis. (A) Comparison of preoperative ctDNA status in pCR and non-pCR. P values were calculated by Fisher’s exact test. (B) Comparison of preoperative ctDNA status in TRG 1–4 group. P values were calculated by Fisher’s exact test. (C-D) Kaplan-Meier (K-M) curves for disease-free survival (DFS) between distinct pCR (left) and preoperative ctDNA status (right). P values were calculated by log-rank test and hazard ratios (HR) were estimated by Cox proportional hazards model. (E) K-M curves for DFS analysis between patients stratified by pCR and preoperative ctDNA status. P values were calculated by log-rank test. (F) Coefficients of multivariable Cox model with clinical risk factors and preoperative ctDNA status. (G-H) Comparison of preoperative ctDNA status between different pathological tumor and nodal stages (ypT and ypN). P values were calculated by Fisher’s exact test. (I-J) Proportion of patients for pCR and preoperative ctDNA status in different arms of neoadjuvant therapy (Nivo + chemo vs. Chemo). P values were calculated by Fisher’s exact test

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Molecular Cancer

ISSN: 1476-4598