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Fig. 6 | Molecular Cancer

Fig. 6

From: Perioperative nivolumab and chemotherapy in locally advanced squamous cell carcinoma of the oesophagus: a randomized multicentre phase 2 study with circulating tumor DNA dynamics monitoring

Fig. 6

Dynamic monitoring of longitudinal MRD. (A) Swimmer plot for 43 enrolled patients with distinct treatment options, ctDNA status at each time and recurrence status for longitudinal monitoring. (B) K-M curves between patients with different longitudinal ctDNA status for DFS and OS. P values were calculated by log-rank test and HR were estimated by Cox proportional hazards model. (C) Coefficients of multivariable Cox model with clinical risk factors and longitudinal ctDNA status. (D) K-M curves for DFS and OS between patients stratified by landmark ctDNA status and whether or not receiving adjuvant therapy. P values were calculated by log-rank test. (E) Sankey plot of ctDNA status at landmark and the follow-up monitoring timepoints, and the recurrence status for 34 patients receiving adjuvant therapy

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Molecular Cancer

ISSN: 1476-4598