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Table 1 Baseline characteristics of ITT patients

From: Perioperative nivolumab and chemotherapy in locally advanced squamous cell carcinoma of the oesophagus: a randomized multicentre phase 2 study with circulating tumor DNA dynamics monitoring

 

Nivo + chemo

Chemo

Characteristic

(n = 60)

(n = 30)

Age (%)

62.59 ± 7.48

65.10 ± 6.42

< 65 years

33 (55)

16 (53.3)

≥ 65 years

27 (45)

14 (46.7)

Gender (%)

  

Female

10 (16.7)

4 (13.3)

Male

50 (83.3)

26 (86.7)

Tumor location (%)

  

Upper thoracic

9 (15)

4 (13.3)

Middle thoracic

34 (56.7)

16 (53.3)

Lower thoracic

17 (28.3)

10 (16.7)

BMI (%)

22.63 ± 2.87

23.72 ± 2.50

≤ 25

42 (70)

20 (66.7)

> 25

10 (16.7)

8 (26.7)

NA

8 (13.3)

2 (6.6)

ECOG (%)

  

0

6 (10)

1 (3.3)

1

54 (90)

29 (96.7)

Median tumor diameter (mm)

14.84 ± 5.21

14.78 ± 6.35

Median tumor length (mm)

46.80 ± 18.76

45.44 ± 17.31

Clinical stage (%)

  

cII

10 (16.7)

5 (16.7)

cIII

50 (83.3)

25 (83.3)

RECIST (%)

  

PR

52 (86.7)

26 (86.7)

SD

4 (6.7)

4 (13.3)

PD

3 (5)

0

NA

1 (1.6)

0

PD-L1 expression – TPS (%)

  

TPS < 1%

30 (50)

1 (3.3)

TPS 1–49%

15 (25)

2 (6.7)

Non-evaluable

15 (25)

27 (90)

PD-L1 expression – CPS (%)

  

CPS < 1

12 (20)

0

CPS ≥ 1, < 5

20 (33.3)

0

CPS ≥ 5, < 10

7 (11.7)

2 (6.7)

CPS ≥ 10

6 (10)

1 (3.3)

Non-evaluable

15 (25)

27 (90)

  1. Abv: BMI, body mass index; ECOG, Eastern Cooperative Oncology Group