Fig. 5
From: Dissecting small cell carcinoma of the esophagus ecosystem by single-cell transcriptomic analysis
Ecotypes of TME components among different tissue origins and their clinical relevance. A Unsupervised hierarchical clustering of 66 TME cell subsets (left) and tissue preferable distribution estimated by Ro/e, shown in heatmap (right). B Five ecotypes identified based on 66 TME cell subsets (left) and GO enrichment analysis based on gene signatures of five ecotypes. C Relative signature expression of five ecotypes among 31 samples (left) and ecotype assignment in SCCE cohort (right). D, E Clinical relevance of EC1 and EC5 in SCCE RNA-seq external validation cohort. F Relationship of EC1 signature expression and molecular subtype of SCCE. G Clinical relevance of EC1 in SCCE-A subtype