Fig. 6
From: Dissecting small cell carcinoma of the esophagus ecosystem by single-cell transcriptomic analysis
Heterogeneity of SCCE defined by classical TFs expression and metaprograms. A Expression of neuroendocrine markers on single cell level from ten patients, including ASCL1, NEUROD1, HNF4G, NEUROD2, FOXA3, YAP1, POU2P3. B Expression of signatures of SCCE-A/N among four SCCE molecule subtypes, shown in heatmap. C Composition of different subtypes of epithelial cells in each SCCE patient. D Gene set enrichment with signature genes of each MP and the significantly enriched gens sets from MSigDB HALLMARK collection are shown. E Scaled signature scores of each MP (rows) across all individual malignant cells (columns). Cells are ordered based on the strength of the GM signature score. F Relationship of each pair of metaprogram. G Clinical relevance of MP5 in SCCE RNA-seq external validation cohort