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Fig. 2 | Molecular Cancer

Fig. 2

From: Profiling triple-negative breast cancer-specific super-enhancers identifies high-risk mesenchymal development subtype and BETi-Targetable vulnerabilities

Fig. 2

Heterogeneous subtype defined by TNBC-Specific SEs. (a) NMF analysis of TNBC-specific SE H3K27ac signals in TNBC cell lines and NMF analysis of TNBC samples based on the expression of the TNBC-specific SE target genes. (b) Enrichment analysis of signature genes from different NMF subtypes based on TNBC-specific SE H3K27ac signals or target genes. The enrichment analysis results were categorized into different functional groups. (c) Workflow for extracting TNBC tumor cells from scRNA-Seq datasets. (d) NMF analysis of TNBC tumor cells based on the expression of the TNBC-specific SE target genes. (e) Enrichment analysis of signature genes from different NMF subtypes based on TNBC-specific SE target genes in TNBC tumor cells. (f) Dataset sources, lesion locations, SCSA functional subtypes, and different NMF subtypes of TNBC tumor cells.

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Molecular Cancer

ISSN: 1476-4598