Fig. 4
From: Multimodal lung cancer theranostics via manganese phosphate/quercetin particle
Pharmacodynamic mechanism of AHA@MnP/QCT NPs. (A) Volcano plots showing DEGs between AHA@MnP NPs (labeled: AM) and Control (labeled: Ctrl), AHA@MnP/QCT NPs (labeled: AMQ) and Ctrl; (B) Heatmap depicting the enrichment of upregulated genes between AM and Ctrl, AMQ and Ctrl; (C) Heatmap depicting the enrichment of down-regulated genes between AM and Ctrl, AMQ and Ctrl; (D) Box plot depicting the enrichment of Ctrl, AM, and AMQ in ROS-related genes; (E) Heatmap depicting the expression levels of Ctrl, AM, and AMQ in ROS-related genes; (F) The GESA plot showed that the TNF signaling pathway, necroptosis, and apoptosis pathways were up-regulated in the AM and AMQ group compared with the Ctrl group; (G) Bar graph depicting the proportion of necroptosis and apoptotic pathway upregulated in AM and AMQ group