Scheme 1
From: Multimodal lung cancer theranostics via manganese phosphate/quercetin particle
Schema of the preparation of AHA@MnP/QCT nanoparticles and its one-stone-for-two-birds strategy to attain the integrated diagnosis and treatment of non-small cell lung cancer. The AHA@MnP/QCT NPs vector sustainably releases QCT and Mn2+ into the acidic environment, which induces apoptosis and promotes ferroptosis in cells via the Fenton-like reactions. Free Mn2+ induces immunogenic cell death by activating DCs and promoting the activation and proliferation of T cells. Non-invasive imaging is achieved by accumulating AHA@MnP/QCT and enhancing T2-MRI signal at the tumor site